Enteral Feeding During Chemoradiotherapy for Advanced Head-and-Neck Cancer: A Single-Institution Experience Using a Reactive Approach

作者: Sébastien Clavel , Bernard Fortin , Philippe Després , David Donath , Denis Soulières

DOI: 10.1016/J.IJROBP.2009.12.032

关键词:

摘要: Purpose The optimal method for providing enteral nutrition to patients with head-and-neck cancer is unclear. The purpose of the present study was evaluate safety and efficacy our reactive policy, which consists installation a nasogastric (NG) feeding tube only when required by patient's nutritional status. Methods Materials records all Stage III IV treated concomitant chemotherapy radiotherapy between January 2003 December 2006 were reviewed. overall disease-free survival rates estimated using Kaplan-Meier compared log–rank test. Results included 253 patients, median follow-up 33 months. At 3 years, rate 82.8% 77.8%, respectively, whole population. No difference observed according presence absence NG or stratified weight loss quartile. mean during treatment 10.4%. proportion requiring 49.8%, remained in place duration 40 days. major complications associated installation. Only 3% still dependent on at 6 Conclusion These results suggest that use an interdisciplinary team approach safe effective manage malnutrition cancer.

参考文章(31)
Gerald B. Brookes, Nutritional status--a prognostic indicator in head and neck cancer. Otolaryngology-Head and Neck Surgery. ,vol. 93, pp. 69- 74 ,(1985) , 10.1177/019459988509300114
Walton Gm, Complications of percutaneous gastrostomy in patients with head and neck cancer--an analysis of 42 consecutive patients. Annals of The Royal College of Surgeons of England. ,vol. 81, pp. 272- 276 ,(1999)
Rosemarie Mick, Everett E. Vokes, Ralph R. Weichselbaum, William R. Panje, Prognostic factors in advanced head and neck cancer patients undergoing multimodality therapy. Otolaryngology-Head and Neck Surgery. ,vol. 105, pp. 62- 73 ,(1991) , 10.1177/019459989110500109
R.G.J. Wiggenraad, L. Flierman, A. Goossens, R. Brand, H.P. Verschuur, G.A. Croll, L.E.C. Moser, R. Vriesendorp, Prophylactic gastrostomy placement and early tube feeding may limit loss of weight during chemoradiotherapy for advanced head and neck cancer, a preliminary study. Clinical Otolaryngology. ,vol. 32, pp. 384- 390 ,(2007) , 10.1111/J.1749-4486.2007.01533.X
Merrill S. Kies, Daniel J. Haraf, Fred Rosen, Kerstin Stenson, Marcy List, Bruce Brockstein, Theodore Chung, Bharat B. Mittal, Harold Pelzer, Louis Portugal, Alfred Rademaker, Ralph Weichselbaum, Everett E. Vokes, Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer. Journal of Clinical Oncology. ,vol. 19, pp. 1961- 1969 ,(2001) , 10.1200/JCO.2001.19.7.1961
Nam P. Nguyen, Debra North, Herbert J. Smith, Suresh Dutta, Alan Alfieri, Ulf Karlsson, Howard Lee, Tomas Martinez, Claire Lemanski, Ly M. Nguyen, Adir Ludin, Sabah Sallah, Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation. Surgical Oncology-oxford. ,vol. 15, pp. 199- 203 ,(2006) , 10.1016/J.SURONC.2006.12.002
Rachel Rabinovitch, Barbara Grant, Brian A. Berkey, David Raben, Kie Kian Ang, Karen K. Fu, Jay S. Cooper, , Impact of nutrition support on treatment outcome in patients with locally advanced head and neck squamous cell cancer treated with definitive radiotherapy: a secondary analysis of RTOG trial 90-03. Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 28, pp. 287- 296 ,(2006) , 10.1002/HED.20335
Tarek M. Mekhail, David J. Adelstein, Lisa A. Rybicki, Marjorie A. Larto, Jerrold P. Saxton, Pierre Lavertu, Enteral nutrition during the treatment of head and neck carcinoma: is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube? Cancer. ,vol. 91, pp. 1785- 1790 ,(2001) , 10.1002/1097-0142(20010501)91:9<1785::AID-CNCR1197>3.0.CO;2-1