Virologic and neurohistologic findings in dairy goats affected with natural scrapie.

摘要: Virologic and neurohistologic findings in three dairy goats that became affected with scrapie while living naturally infected Suffolk sheep were essentially like those sheep. Virus, detected by mouse inoculation, was widespread non-neural sites, particularly lymphatic tissues intestine. Im most titers of virus ranged from 3.0 to 3.5 log10 intracerebral LD50/30 mg tissue. Virus nervous tissue much higher titer. Ranging 5.1 5.8 log10, the highest mean diencephalon, midbrain, medulla oblongata cerebellar cortex--sites severe histologic changes. Although these changes sheep, they differed somewhat experimental disease. Spongiform alteration neuropil minimal, more rostral parts brain, such as corpus striatum, globus pallidus septal area, had few Concentrations distribution consistent conclusion no doubt can be maintained contagion a herd apart