Matrix Metalloproteinase-9-Responsive Surface Charge-Reversible Nanocarrier to Enhance Endocytosis as Efficient Targeted Delivery System for Cancer Diagnosis and Therapy.
作者： Qiang-Zhe Zhang , Lu-Yuan Li , Long Yi , Zhen Xi , Chuan-Zeng Zhang
关键词:
摘要: Nanoparticles, that can be enriched in the tumor microenvironment and deliver payloads into cancer cells, are desirable carriers for theranostic agents diagnosis treatment. However, efficient targeted delivery enhanced endocytosis probes drugs theranostics still major challenges. Here, a nanoparticle, which is capable of charge reversal from negative to positive response matrix metalloproteinase 9 (MMP9) reported. This nanoparticle based on novel reversible amphiphilic molecule consisting hydrophobic oleic acid, MMP9-cleavable peptide, glutamate-rich segment (named as OMPE). The OMPE-modified cationic liposome forms an intelligent anionic nanohybrid (O-NP) with through surface MMP9 vitro. Successfully, O-NP performs preferential accumulation enhances MMP9-expressing xenografted tumors mouse models, improve sensitivity antitumor effects vivo by overcoming their low solubility and/or nonspecific enrichment. These results indicate promising platform therapy.
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