Psychopathologic structure of bipolar disorders: exploring dimensional phenotypes, their relationships, and their associations with bipolar I and II disorders.

摘要: BackgroundGiven its diverse disease courses and symptom presentations, multiple phenotype dimensions with different biological underpinnings are expected bipolar disorders (BPs). In this study, we aimed to identify lifetime BP psychopathology dimensions. We also explored the differing associations I (BP-I) II (BP-II) disorders.MethodsWe included a total of 307 subjects BPs in analysis. For factor analysis, chose six variables related clinical courses, 29 indicators covering symptoms mood episodes, 6 specific comorbid conditions. To determine relationships among identified phenotypic their effects on differentiating subtypes, applied structural equation modeling.ResultsWe selected six-factor solution through scree plot, Velicer's minimum average partial test, face validity evaluations; factors were cyclicity, depression, atypical vegetative symptoms, elation, psychotic/irritable mania, comorbidity. path five excluding associated one another. Cyclicity, comorbidity had positive associations, they correlated negatively mania; elation showed correlations cyclicity mania. Depression, stronger BP-II than BP-I, contributed significantly distinction between two disorders.ConclusionsWe dimensions; addition features manic depressive various comorbidities high constructed separate Except for all complex interdependency played roles discriminating from BP-I.