Reduced High-Molecular-Weight Adiponectin and Elevated High-Sensitivity C-Reactive Protein Are Synergistic Risk Factors for Metabolic Syndrome in a Large-Scale Middle-Aged to Elderly Population: the Shimanami Health Promoting Program Study
作者： Yasuharu Tabara , Haruhiko Osawa , Ryuichi Kawamoto , Rieko Tachibana-Iimori , Miyuki Yamamoto
DOI: 10.1210/JC.2007-0397
关键词:
摘要: Objective: In Western countries, one of the most important modifiable targets for prevention cardiovascular diseases is metabolic syndrome. Adiponectin an adipose tissue-specific plasma protein that inversely associates with Among several molecular isoforms, high-molecular-weight (HMW) complex considered active form. Increased serum high-sensitivity C-reactive (hsCRP) concentration also syndrome, and adiponectin could modulate levels. Here, through cross-sectional investigation, we investigated whether reduced HMW increased hsCRP levels in are synergistically associated Measurement novelties this study. Design: We analyzed 1845 community-dwelling middle-aged to elderly subjects (62 ± 13 yr). Plasma were measured by ELISA. Clinical parameters obtained from subjects’ personal health reco...
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