Immunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease.

摘要: Activation of the Akt-mTORC1 signaling pathway was evaluated in premalignant and hepatocellular carcinoma (HCC) lesions by assessing expression pS6, an Akt effector, PTEN, suppressor. Methods: Immunohistochemical staining for pS6 PTEN performed on liver tissue from 52 patients with cirrhosis, without HCC. Two pathologists independently a semiquantitative scale categorized as present or absent. Results: In HCC group, greatest HCC, followed dysplasia, benign cirrhotic (P < 0.001). greater compared to cirrhosis = 0.03). tumor absent 8/33 (24%) cases. Loss more common higher stage, those stage 1 tumors 0.04). Conclusion: evidence activation is associated