Synthesis and Structure of 3,4-Dihydropyrido[2′,3′:3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amines
作者： Anton V. Dolzhenko , Shiqi Bai , Anna V. Dolzhenko , Wai Keung Chui
DOI: 10.1002/JHET.851
关键词:
摘要: A new convenient synthon for heterocyclic chemistry, namely 1H-pyrazolo[3,4-b]pyridin-3-ylguanidine was successfully prepared by selective guanylation of 1H-pyrazolo[3,4-b]pyridin-3-amine. series 3,4-dihydropyrido[2′,3′:3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amines synthesized from using aldehydes or ketones as one-carbon inserting reagents. The tautomeric preferences the products were determined spectroscopic (e.g., 2D NOESY NMR) and single crystal X-ray diffraction data.
curtin.edu.au参考文章(10)
Anton V. Dolzhenko, Wai-Keung Chui, Anna V. Dolzhenko, Synthesis of ethyl 6‐aryl‐4‐oxo‐4,6‐dihydro‐1(12)(13)h‐pyrimido‐[2′,1′:4,5][1,3,5]triazino[1,2‐a]benzimidazole‐3‐carboxylates Journal of Heterocyclic Chemistry. ,vol. 43, pp. 1513- 1521 ,(2006) , 10.1002/JHET.5570430614
Anton Dolzhenko, M Foo, B Tan, A Dolzhenko, G Chiu, W Chui, Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents HETEROCYCLES. ,vol. 78, pp. 1761- 1775 ,(2009) , 10.3987/COM-09-11672
Anton V. Dolzhenko, Anna V. Dolzhenko, Wai‐Keung Chui, Simple synthesis of 2-amino-4-(het)aryl-4,6-dihydro-1(3)(11)H-[1,3,5]triazino[2,1-b]quinazolin-6-ones Journal of Heterocyclic Chemistry. ,vol. 45, pp. 173- 176 ,(2008) , 10.1002/JHET.5570450119
Anton V Dolzhenko, Bee Jen Tan, Anna V Dolzhenko, Gigi Ngar Chee Chiu, Wai Keung Chui, None, Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines. Journal of Fluorine Chemistry. ,vol. 129, pp. 429- 434 ,(2008) , 10.1016/J.JFLUCHEM.2008.02.007
A. V. Dolzhenko, W. K. Chui, Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2-amines. Pharmaceutical Chemistry Journal. ,vol. 41, pp. 470- 473 ,(2007) , 10.1007/S11094-007-0103-5
Anton V. Dolzhenko, Wai-Keung Chui, Anna V. Dolzhenko, Lai-Wah Chan, Synthesis and biological activity of fluorinated 2-amino-4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazoles Journal of Fluorine Chemistry. ,vol. 126, pp. 759- 763 ,(2005) , 10.1016/J.JFLUCHEM.2005.02.009
Anton V. Dolzhenko, Giorgia Pastorin, Anna V. Dolzhenko, Wai Keung Chui, A convenient method for the synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines Tetrahedron Letters. ,vol. 49, pp. 7180- 7183 ,(2008) , 10.1016/J.TETLET.2008.10.003
Wai-Keung Chui, Anton V. Dolzhenko, Anna V. Dolzhenko, Pyrazolo[1,5-a][1,3,5]triazines (5-Aza-9-deazapurines): Synthesis and Biological Activity HETEROCYCLES. ,vol. 75, pp. 1575- 1622 ,(2008) , 10.3987/REV-08-629
Anton V. Dolzhenko, Anna V. Dolzhenko, Wai-Keung Chui, Practical synthesis of regioisomeric 5(7)-amino-6,7(4,5)-dihydro [1,2,4 ]triazolo [1,5 -a ] [1,3,5 ]triazines Tetrahedron. ,vol. 63, pp. 12888- 12895 ,(2007) , 10.1016/J.TET.2007.10.046
Anton V. Dolzhenko, Wai-Keung Chui, Synthesis of 2-amino-s-triazino[1,2-a]benzimidazoles as potential antifolates from 2-guanidino- and 2-guanidino-5-methylbenzimidazoles Journal of Heterocyclic Chemistry. ,vol. 43, pp. 95- 100 ,(2006) , 10.1002/JHET.5570430115