Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials.
作者： Mark H. Greene , John D. Boice , Benjamin E. Greer , John A. Blessing , Alon J. Dembo
DOI: 10.1056/NEJM198212023072302
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摘要: Abstract We evaluated the occurrence of acute nonlymphocytic leukemia (and) among 1399 women with ovarian cancer who were treated in five randomized clinical trials. Of women, 998 had been alkylating agents, and these, 12 cases observed; expected number was 0.11. Ten patients received melphalan, two chlorambucil, not observed 401 surgery or radiation both, without agents. The excess risk that associated alkylating-agent therapy 5.8 per 1000 year, cumulative seven-year 9.6±3.3 cent (±S.E.). chemotherapy alone indistinguishable from receiving both chemotherapy. A positive correlation between initial drug dose suggested. These data underscore need to assess other cytotoxic agents regimens admini...
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