Relationship between abdominal pain subgroups in the community and psychiatric diagnosis and personality A birth cohort study

摘要: Abstract Introduction: It is unclear if there a causal link between psychiatric disorders and unexplained chronic gastrointestinal (GI) symptomatology. The role of personality also in dispute. We aimed to assess the association these factors with functional GI symptoms birth cohort study. Methods: Dunedin well characterised has been followed-up prospectively age 26 ( n =980). Measured were upper lower over prior year at using validated questionnaire, diagnoses ages 18 21 by standardised interview applying DSM-III-R criteria, Multidimensional Personality Questionnaire (MPQ). Natural symptom groupings identified factor analysis k -means clustering. clusters or was assessed logistic regression. Results: produced six-cluster solution, which made up health group, five “disease” defined higher than average scores on single symptom. A diagnosis depression years associated increases odds 1.69 (95% CI: 1.27–2.25) for all GI, 2.16 1.12–4.16) dysmotility 2.07 1.13–3.80) constipation, but not other clusters. Similar results observed respect anxiety overall (OR=1.42, 95% 1.01–1.99) constipation (OR=2.11, 1.17–3.79). subscales strongly linked; membership “any” diseased cluster reduced being fourth quartile well-being scale (OR=0.64, 0.46–0.88) increased social potency (OR=1.64, 1.18–2.28). Conclusions: In young adult community sample, appear be linked differences minimal.