Patient preferences for treatment of multiple sclerosis with disease-modifying therapies: a discrete choice experiment

摘要: OBJECTIVES To assess disease-modifying therapy (DMT) preferences in a population of patients with multiple sclerosis (MS) and to estimate the association between sociodemographic clinical factors these preferences. METHODS Preferences for DMTs attributes were measured using discrete choice experiment. Analysis was assessed mixed-logit hierarchical Bayes regression. A multilinear regression used evaluate each attribute patients' demographic characteristics. Student's t-test or Welch's subgroup comparisons. RESULTS total 125 included final analysis (62.9% female, mean age 44.5 years, 71.5% relapsing-remitting MS diagnosis). The most important factor possibility suffering from side effects treatment (relative importance [RI] =50%), followed by delay disease progression (RI =19.4%), route frequency administration =14.3%). According maximum acceptable risk, willing accept an increase 3.8% severity effects, 1 year progression. Treatment duration prevalent affecting preferences, patients, type MS, level education, current treatment. Patients treated orally significantly more concerned about (P=0.026) than on injectable therapy. Naive stated less prevention relapses (P=0.021) deterioration capacity performing usual daily life activities (P=0.015). Finally, >5 years since diagnosis preventing (P=0.021), (P=0.052) compared <5 history. CONCLUSION DMTs, disability Experience time changed These results give information adjust new DMT order satisfy therefore, improve adherence