Matters of context guide future research in TGFβ superfamily signaling
作者： Rosemary J. Akhurst , Richard W. Padgett
DOI: 10.1126/SCISIGNAL.AAD0416
关键词:
摘要: The highly conserved wiring of the SMAD-dependent transforming growth factor β (TGFβ) superfamily signaling pathway has been mapped over last 20 years after molecular discovery its component parts. Numerous alternative TGFβ-activated pathways that elicit SMAD-independent biological responses also exist. However, mechanisms responsible for renowned context dependency TGFβ output remains an active and often confounding area research, providing a prototype relevant to regulation other pathways. Highlighting discoveries presented at 9th FASEB meeting, Superfamily: Signaling in Development Disease (July 12-17th 2015 Snowmass, Colorado), this Review outlines research into rich contextual nature offers clues therapeutic advances.
sciencemag.org参考文章(118)
Zhiyu Liu, Herong Shi, Lindsey C Szymczak, Taner Aydin, Sijung Yun, Katharine Constas, Arielle Schaeffer, Sinthu Ranjan, Saad Kubba, Emad Alam, Devin E McMahon, Jingpeng He, Neta Shwartz, Chenxi Tian, Yevgeniy Plavskin, Amanda Lindy, Nimra Amir Dad, Sunny Sheth, Nirav M Amin, Stephanie Zimmerman, Dennis Liu, Erich M Schwarz, Harold Smith, Michael W Krause, Jun Liu, None, Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids PLOS Genetics. ,vol. 11, pp. e1005221- ,(2015) , 10.1371/JOURNAL.PGEN.1005221
E. Bier, E. M. De Robertis, BMP gradients: A paradigm for morphogen-mediated developmental patterning Science. ,vol. 348, ,(2015) , 10.1126/SCIENCE.AAA5838
Sandrine Levet, Marie Ouarné, Delphine Ciais, Charles Coutton, Mariela Subileau, Christine Mallet, Nicolas Ricard, Marie Bidart, Thierry Debillon, Francesca Faravelli, Caroline Rooryck, Jean-Jacques Feige, Emmanuelle Tillet, Sabine Bailly, BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 201508386- ,(2015) , 10.1073/PNAS.1508386112
Kangmin He, Xiaohua Yan, Nan Li, Song Dang, Li Xu, Bing Zhao, Zijian Li, Zhizhen Lv, Xiaohong Fang, Youyi Zhang, Ye-Guang Chen, Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes. Cell Research. ,vol. 25, pp. 738- 752 ,(2015) , 10.1038/CR.2015.60
Felipe-Andrés Ramírez-Weber, Thomas B Kornberg, Cytonemes: Cellular Processes that Project to the Principal Signaling Center in Drosophila Imaginal Discs Cell. ,vol. 97, pp. 599- 607 ,(1999) , 10.1016/S0092-8674(00)80771-0
Lalage M. Wakefield, Caroline S. Hill, Beyond TGFβ: roles of other TGFβ superfamily members in cancer Nature Reviews Cancer. ,vol. 13, pp. 328- 341 ,(2013) , 10.1038/NRC3500
Sougata Roy, Thomas B. Kornberg, Paracrine signaling mediated at cell-cell contacts BioEssays. ,vol. 37, pp. 25- 33 ,(2015) , 10.1002/BIES.201400122
J. Kaiser, ‘Rejuvenating’ protein doubted Science. ,vol. 348, pp. 849- 849 ,(2015) , 10.1126/SCIENCE.348.6237.849
L M Wakefield, D M Smith, K C Flanders, M B Sporn, Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences. Journal of Biological Chemistry. ,vol. 263, pp. 7646- 7654 ,(1988) , 10.1016/S0021-9258(18)68547-3
Marcus Kretzschmar, Jacqueline Doody, Joan Massagu, Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1 Nature. ,vol. 389, pp. 618- 622 ,(1997) , 10.1038/39348