NMDA receptor activation and early olfactory learning.

作者: Jann Lincoln , Robert Coopersmith , Eric W. Harris , Carl W. Cotman , Michael Leon

DOI: 10.1016/0165-3806(88)90036-3

关键词:

摘要: Abstract Norway rat pups have an enhanced olfactory bulb response to odors which they learned prefer early in life. When N- methyl- d -aspartate receptors are blocked pharmacologically before preference training, both the behavioral and odor suppressed. These results implicate activation of these kind neural plasticity that normally occurs during development.

参考文章(17)
DT Monaghan, CW Cotman, Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain The Journal of Neuroscience. ,vol. 5, pp. 2909- 2919 ,(1985) , 10.1523/JNEUROSCI.05-11-02909.1985
R Coopersmith, M Leon, Enhanced neural response to familiar olfactory cues Science. ,vol. 225, pp. 849- 851 ,(1984) , 10.1126/SCIENCE.6474157
Eric W. Harris, Alan H. Ganong, Carl W. Cotman, Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors Brain Research. ,vol. 323, pp. 132- 137 ,(1984) , 10.1016/0006-8993(84)90275-0
Regina M. Sullivan, Michael Leon, Early olfactory learning induces an enhanced olfactory bulb response in young rats. Brain Research. ,vol. 392, pp. 278- 282 ,(1986) , 10.1016/0165-3806(86)90256-7
A Kleinschmidt, M. Bear, W Singer, Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex Science. ,vol. 238, pp. 355- 358 ,(1987) , 10.1126/SCIENCE.2443978
Kevin J. Anderson, Daniel T. Monaghan, Charles B. Cangro, M.A.A. Namboodiri, Joseph H. Neale, Carl W. Cotman, Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain Neuroscience Letters. ,vol. 72, pp. 14- 20 ,(1986) , 10.1016/0304-3940(86)90610-5
Robert Coopersmith, Steven R. Henderson, Michael Leon, Odor specificity of the enhanced neural response following early odor experience in rats. Developmental Brain Research. ,vol. 27, pp. 191- 197 ,(1986) , 10.1016/0165-3806(86)90245-2
Cynthia C. Woo, Michael Leon, Sensitive period for neural and behavioral response development to learned odors. Developmental Brain Research. ,vol. 36, pp. 309- 313 ,(1987) , 10.1016/0165-3806(87)90038-1
Cynthia C. Woo, Robert Coopersmith, Michael Leon, Localized changes in olfactory bulb morphology associated with early olfactory learning. The Journal of Comparative Neurology. ,vol. 263, pp. 113- 125 ,(1987) , 10.1002/CNE.902630110
R. G. M. Morris, E. Anderson, G. S. Lynch, M. Baudry, Selective impairment of learning and blockade of long-term potentiation by an N -methyl-D-aspartate receptor antagonist, AP5 Nature. ,vol. 319, pp. 774- 776 ,(1986) , 10.1038/319774A0