An Automated and Qualified Platform Method for Site-Specific Succinimide and Deamidation Quantitation Using Low-pH Peptide Mapping

作者: Mingyan Cao , Weichen Xu , Ben Niu , Ivy Kabundi , Haibin Luo

DOI: 10.1016/J.XPHS.2019.07.019

关键词:

摘要: … Thus, unlike conventional peptide mapping, low-pH digestion peptide mapping did not yield the artifact of asparagine deamidation during digestion. The association between …

参考文章(32)
Neelima P. Bhatt, Kamlesh Patel, Ronald T. Borchardt, Chemical pathways of peptide degradation. I. Deamidation of adrenocorticotropic hormone. Pharmaceutical Research. ,vol. 7, pp. 593- 599 ,(1990) , 10.1023/A:1015862026539
Cecilia Oliyai, Jitendra P. Patel, Linda Carr, Ronald T. Borchardt, Chemical pathways of peptide degradation. VII. Solid state chemical instability of an aspartyl residue in a model hexapeptide. Pharmaceutical Research. ,vol. 11, pp. 901- 908 ,(1994) , 10.1023/A:1018998312503
John Valliere-Douglass, Laura Jones, Diana Shpektor, Paul Kodama, Alison Wallace, Alain Balland, Robert Bailey, Yuling Zhang, Separation and characterization of an IgG2 antibody containing a cyclic imide in CDR1 of light chain by hydrophobic interaction chromatography and mass spectrometry. Analytical Chemistry. ,vol. 80, pp. 3168- 3174 ,(2008) , 10.1021/AC702245C
Lihua Huang, Jirong Lu, Victor J. Wroblewski, John M. Beals, Ralph M. Riggin, In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS Analytical Chemistry. ,vol. 77, pp. 1432- 1439 ,(2005) , 10.1021/AC0494174
Reed J. Harris, Bruce Kabakoff, Frank D. Macchi, Felicity J. Shen, May Kwong, James D. Andya, Steven J. Shire, Nancy Bjork, Klara Totpal, Anthony B. Chen, Identification of multiple sources of charge heterogeneity in a recombinant antibody. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 752, pp. 233- 245 ,(2001) , 10.1016/S0378-4347(00)00548-X
Grace C. Chu, Dirk Chelius, Gang Xiao, Hui K. Khor, Sururat Coulibaly, Pavel V. Bondarenko, Accumulation of Succinimide in a Recombinant Monoclonal Antibody in Mildly Acidic Buffers Under Elevated Temperatures Pharmaceutical Research. ,vol. 24, pp. 1145- 1156 ,(2007) , 10.1007/S11095-007-9241-4
Minli Xie, David Vander Velde, Martha Morton, Ronald T. Borchardt, Richard L. Schowen, pH-induced change in the rate-determining step for the hydrolysis of the Asp/Asn-derived cyclic-imide intermediate in protein degradation Journal of the American Chemical Society. ,vol. 118, pp. 8955- 8956 ,(1996) , 10.1021/JA9606182