Fluorine-18 labelled building blocks for PET tracer synthesis.
作者： Dion van der Born , Anna Pees , Alex J. Poot , Romano V. A. Orru , Albert D. Windhorst
DOI: 10.1039/C6CS00492J
关键词:
摘要: Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 the most widely used radioisotope PET imaging and a thorough overview of available radiochemistry methodology prerequisite selection synthetic approach new fluorine-18 labelled tracers. These tracers can be synthesised either by late-stage radiofluorination, introducing in last step synthesis, or building block (also called modular build-up approach), fast efficient manner block, which reacted further one multiple reaction steps to form tracer. This review presents comprehensive synthesis application blocks since 2010.
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