The Effect of Eight Weeks of High-Intensity Interval Training on Gene Expression of Angiogenesis Factors in Ischemic Rats

摘要: Background and Objective: Myocardial infraction can lead to loss of heart muscle cell, changes in ventricular function structure, scar formation as well leading the ultimate stroke its loss. This study aimed investigate effect eight weeks High-Intensity Interval Training (HIIT) on gene expression angiogenesis factors ischemic rats. Materials Methods: In this study, 28 male Wistar rats (200-250 g) were randomly assigned 4 groups: sham, ischemia, exercise, exercise-ischemia. infarction (MI) was achieved via closure LAD artery for 30 minutes. A treadmill exercise program performed by 8 weeks, 40 minutes daily, 3 days a week. Results: The results showed that there is significant difference between four groups levels VEGF, apelin receptor (p = 0.001). Results also level significantly increased exercise-ischemia group compared sham 0.04), ischemia 0.002) 0.009) groups. during an increase VEGF but not alone. On other hand, observed following intervention 0.025). No interval training > 0.05). Meanwhile, reduction seen 0.04). Conclusion: physiological adaptations caused are associated with different expressions. regular leads involved regeneration cardiac vessels myocardial ischemia. © 2018, Zanjan University Medical Sciences Health Services. All rights reserved.