Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease.

摘要: Background and Aim:  6-Mercaptopurine (6-MP) azathioprine (AZA) are widely used as maintenance therapy in children with inflammatory bowel disease (IBD). However, proper 6-thioguanine nucleotide (6-TGN) concentrations Japanese IBD have not been reported. Methods:  This retrospective review examines 32 ulcerative colitis (UC) patients 19 Crohn's (CD) (12.87 ± 3.56 years) who required 6-MP or AZA to maintain remission. All were treated for at least 3 weeks prior this study addition previous treatment. dose, 6-TGN levels, assayed by high-performance liquid chromatography, well laboratory data evaluated. Results:  Thirty-five successfully kept remission after weaning off corticosteroids. Overall, 123 measurements (59 active disease, 64 remission) analyzed. The mean concentration of the entire population was 499.61 ± 249.35 pmol/8 × 108 red blood cell. dose (0.910 ± 0.326 mg/kg per day) significantly higher than (0.749 ± 0.225) (P = 0.0016). A significant inverse correlation found between white cell counts (r = 0.275, P < 0.002). Two experienced leukopenia alopecia, four transiently increased serum levels pancreatic enzymes, although no thiopurine S-methyl transferase mutations confirmed. Conclusion:  doses needed lower those reported Western countries. previously reported.