Gastrointestinal Cancer: Selection of Clinically Relevant Drug-Induced Toxicities Encountered in Gastrointestinal Cancer Treatment

摘要: The chemotherapeutic options have increased dramatically in patients with gastrointestinal cancer and led to an improved outcome. With this, in-depth understanding of the side effects chemotherapy is becoming increasingly important order minimize negative impact use these agents. Chemotherapeutic agents a long list potential effects. In this chapter, we focus specifically on some more common and/or relevant challenging related frequently used cancer. fluoropyrimidines may cause cardiac toxicity, most angina-like chest pain. knowledge catabolism fluorouracil has possibility testing for dihydropyrimidine dehydrogenase (DPD) avoid serious fluorouracil-related toxicity DPD deficiency. Oxaliplatin-induced neurotoxicity probably clinical problem associated administration oxaliplatin. increasing oxaliplatin, hypersensitivity reactions are reported become practice. introduction targeted colorectal also specific problems: anti-VEGF-related effects, which perforation, although relatively rare, very patient, anti-EGFR-related including skin rash, hypomagnesemia, allergic reactions, common. Understanding underlying causes, mechanisms, risk factors, developing treatment guidelines made often acceptable many patients. However, side-effect profile always be balanced against activity benefit anticancer