Blocking pro-cell-death signal pathways to conserve hearing.

摘要: The programmed cell death of stress-damaged auditory hair cells can occur through a variety signal pathways, and therapeutic modalities that block pro-cell-death pathways are being developed evaluated for hearing preservation. Because their ability to have both anti-inflammatory anti-apoptotic actions, corticosteroids long been used protect against several types acute sensorineural loss. Other drugs target the mitogen-activated protein kinase (MAPK)/c-Jun-N terminal (JNK) cascade, such as D-JNKI-1 (AM-111) SP600125, produced promising results in vitro laboratory animal studies, with AM-111 showing promise preliminary clinical trials. Antioxidant drugs, e.g. sodium thiosulfate, N-acetylcysteine, D-methionine, shown studies attenuate permanent threshold shifts by reducing oxidative stress. In addition reviewing selected trends conservation hearing, we review our experiences dexamethasone report from current research.