OBSERVATIONS ON THE EFFECT OF MASSIVE DOSES OF IRON GIVEN INTRAVENOUSLY TO PATIENTS WITH HYPOCHROMIC ANEMIA

摘要: Massive doses of iron (from 0.608 to 1.32 Gm. as colloidal terric hydroxide or ferric oxide) were given intravenously in single infusions 8 different patients with hypochromic microcytic anemia. One patient was a second injection after an interval four months, so that nine administrations made. The following observations made: 1. reticulocyte response higher each instance than would be expected oral therapy. In 3 additional whom had discontinued 0.070, 0.180, and 0.123 elemental respectively been given, the rises average responses reported by Heath18 optimal This at least suggests "optimal" therapy does not provide maximal stimulus outpouring reticulocytes from bone marrow. Comparable control subjects normal hemoglobin levels did cause reticulocytosis. 2. rate regeneration per 100 cc. blood day 0.224 Gm.; lowest value 0.16 highest 0.27 These figures calculated for rise occurred administration time which increase obviously becoming slower. Since correction made loss during period regeneration, formation are lower they otherwise have been. Even distinctly greater those usually obtained (table 2), but no is found occasional mouth. data suggest fastest can stimulated anemia approximates 0.3 day. 3. Calculations indicated 71.8 99.7 cent injected apparently used synthesis hemoglobin. likewise if several lost recovery period. observation other workers parenterally administered almost completely retained body converted into therefore confirmed. 4. Toxic reactions described detail. They severe all two instances, alarming discontinued. There doubt large great enough contra-indicate use this measure therapeutic procedure.