Energetic stress and infection generate immunity-fecundity tradeoffs in Drosophila

摘要: Physiological responses to short-term environmental stress, such as infection, can have long-term consequences for fitness, particularly if the are inappropriate or nutrient resources limited. Genetic variation affecting energy acquisition, storage, and usage limit cellular availability may influence resource-allocation tradeoffs even when nutrients plentiful. Here, we utilized Drosophila mitochondrial-nuclear genotypes test whether disrupted mitochondrial function interferes with nutrient-sensing pathways, this disruption has between immunity fecundity. We found that an energetically-compromised genotype was resistant rapamycin - a drug stimulates pathways activated Dietary resource limitation also decreased survival in genotypes. Together, these results suggest little excess energetic capacity fewer nutrients, not limiting. Accordingly, immune compromised genotype, but only females, females experienced immunity-fecundity were evident genotypic controls normal metabolism. Thus, genetic metabolism act available allocation life-history traits ways generate