Effect of CD44 expression on T cell acute lymphocytic leukemia

摘要: CD44 is a cell surface glycoprotein that serves as multifunctional receptor aiding in trafficking and adhesion of immune cells. also recruitment platform for signaling molecules has been shown to regulate proliferation. In several types leukemia the presence or absence expression associated with different clinical outcomes, patients who have increased exhibiting stronger response conventional chemoand radiotherapy. By using Jurkat T cells, which do not express CD44, determine effects model Acute Lymphocytic Leukemia line, we outlined two major areas study. Firstly, upon cells proliferate slowly compared control This decrease proliferation coupled an arrest cycle during transition from G1 phase into S phase. The dysregulation induced by leads induction aneuploidy. expressing reduced mRNA key regulators chromosome separation mitotic spindle complex. finding, decreased EGR-1 expression, controls cyclins responsible phase, unstable phenotype proliferates accumulates extra chromosomes daughter second area study focuses on mechanism at results observed decreases proliferation, Akt activation, expression. We show four five times higher calcium influx when rest vector due activating inducible release activated channel. excess activates calcium-activated phosphatases kinases, disrupting inducing hypophosphorylation Akt. Together, these findings indicate can signal transduction pathways addition its role adhesion. Thus, our data provide further understanding how modifies leukemic are favorable therapeutic intervention. EFFECT OF EXPRESSION ON CELL ACUTE LYMPHOCYTIC LEUKEMIA