Population Effects of Calcium Phosphate Nanoparticles in Drosophila melanogaster: The Effects of Phase Composition, Crystallinity, and the Pathway of Formation.
作者： Victoria M. Wu , Vuk Uskoković
DOI: 10.1021/ACSBIOMATERIALS.7B00540
关键词:
摘要: Unpredictable biological response due to finest nanostructural variations is one of the hallmarks nanoparticles. Because this erratic behavior nanoparticles in living systems, thorough analyses biosafety must precede pharmacotherapeutic efficacy and simple animal models are ideal for such purposes. Drosophila melanogaster, common fruit fly, an model capable giving a fast, high-throughput as safety drug delivery carriers other pharmacological agents, while minimizing suffering imposed onto animals more complex vivo models. Here we studied effects on viability fertility D. melanogaster phase composition, crystallinity pathway formation four different calcium phosphate (CP) nanopowders consumed orally. To minimize effect variables, CP were made possess highly similar particle sizes morphologies. The composition af...
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