Efficacy and tolerability of Paroxetine 20 mg daily in the treatment of depression and depression associated anxiety.

摘要: OBJECTIVE To assess the efficacy and tolerability of paroxetine 20mg daily, for treatment depression associated with anxiety. METHOD An open, non-comparative study undertaken at three centers in cities Pakistan. A total 112 in- or out-patients, presenting a major depressive episode were included study. Depression was diagnosed according to DSM IV criteria Hamilton Rating Scale (HAMD-D) score >18 on first 17 items HAM-D-21. After placebo washout period 7 days, patients given 20-mg fixed dose daily morning 6 weeks. baseline, regular assessments made 1, 2, 4 Efficacy measures HAMD-D, Clinical Anxiety Scale, The Global Impression Severity Illness (CGI-S), Improvement (CGI-I). Tolerability assessed by any adverse event. primary therapeutic outcome who achieved 50% greater reduction HAMD-D end final < = 10 points. scores 1 2 CGI-S CGI-I considered as full clinical response. RESULTS Of cases evaluated, 57 males 55 females whose ages ranged from 18 65 years. There clear statistically significant all variables. 88% treatment. HAM-D reduced less 73% weeks this week 76% 92% CGI-I, respectively. mean 12.6 baseline 4.4 Safety data evaluated well tolerated. Adverse events experienced 10% whom 4% dropped Nausea commonest event reported. CONCLUSION shows that is an effective, well-tolerated, safe drug depression.