The effects of pregnancy on autoimmune diseases.

摘要: Internal gestation of a genetically foreign conceptus challenges the maternal host to circumvent immunological processes that recognize and eliminate nonself molecules. Accordingly, human viviparity involves wide range modifications. This review examines relationship between pregnancy several autoimmune diseases prevalent in women. Pregnancy is associated with improvement clinical signs symptoms rheumatoid arthritis more than 70% patients. Maternal-fetal disparity alleles HLA-DRbeta1, DQalpha, DQbeta has been reported be pregnancies characterized by remission or improvement. These observations suggest presentation fetal DQalpha peptides might correct autoimmunity patients RA either induction maternal-regulatory T cells, affecting cell receptor repertoire. In contrast, course systemic lupus erythematosus variable. Whether flare rates increase during after unsettled, since individual patient series vary characteristics accepted for study definitions flare. Despite high overall rate some approaching 60%, recorded flares were usually not severe. Only limited data are available regarding incidence outcome mother scleroderma her fetus. The extent diffuse skin disease involvement, particularly pulmonary, cardiac renal, may important duration disease; carries better prognosis Highly specific autoantibody profiles (independent whether she disease) demise neonatal syndromes, most serious manifestation which isolated congenital heart block. former antiphospholipid antibodies latter directed against SSA/Ro SSB/La polypeptides.