Association of HLA-DQA1 gene polymorphisms with the risk of children primary nephrotic syndrome in Chinese population.
作者： Bingbing Zhu , Ruifeng Zhang , Huandan Yang , Tingting Yuan , Juan Lv
DOI: 10.1002/JCLA.22623
关键词:
摘要: Background The association between gene polymorphisms and the risk of primary nephrotic syndrome (PNS) is uncovering recently. This study aims to investigate relationship single nucleotide (SNPs) on HLA-DQA1 PNS. Methods In this study, we genotyped eight in 501 PNS patients 532 healthy people Chinese population. Then analyzed associations these SNPs with clinical features children Results Significant were found missense SNP rs1129740 (GG vs AA, odds ratio (OR) = 1.987, 95% confidence interval (CI) 1.468-2.652, P 0.00177049) rs1047992 (AA GG, OR 1.857, CI 1.325-2.391, 1.1073E-10) gene. Conclusions work suggests are factors for population, which implies roles immune response pathogenesis
sci-hub.se 参考文章(23)
Gilberto Vargas-Alarcón, José Manuel Fragoso, Carlos Tovilla-Zárate, Julián Ramírez-Bello, Polimorfismos de un solo nucleótido (SNP): implicaciones funcionales de los SNP reguladores (rSNP) y de los SNP-ARN estructurales (srSNP) en enfermedades complejas Gaceta Medica De Mexico. ,vol. 149, pp. 220- 228 ,(2013)
W. M. Howell, HLA and disease: guilt by association International Journal of Immunogenetics. ,vol. 41, pp. 1- 12 ,(2014) , 10.1111/IJI.12088
Bing He, Hao Zhang, Tieliu Shi, None, A Comprehensive Analysis of the Dynamic Biological Networks in HCV Induced Hepatocarcinogenesis PLoS ONE. ,vol. 6, pp. e18516- ,(2011) , 10.1371/JOURNAL.PONE.0018516
Allison A Eddy, Jordan M Symons, Nephrotic syndrome in childhood. The Lancet. ,vol. 362, pp. 629- 639 ,(2003) , 10.1016/S0140-6736(03)14184-0
Fang Yang, Xinlong Lai, Li Deng, Xiaoxiao Liu, Jian Li, Shuixiu Zeng, Cheng Zhang, Carl-Friedrich Hocher, Berthold Hocher, Association of endothelin-1 gene polymorphisms with the clinical phenotype in primary nephrotic syndrome of children Life Sciences. ,vol. 118, pp. 446- 450 ,(2014) , 10.1016/J.LFS.2014.04.010
FabrÃcio C. Dias, Erick C. Castelli, Cristhianna V. A. Collares, Philippe Moreau, Eduardo A. Donadi, The Role of HLA-G Molecule and HLA-G Gene Polymorphisms in Tumors, Viral Hepatitis, and Parasitic Diseases Frontiers in Immunology. ,vol. 6, pp. 9- 9 ,(2015) , 10.3389/FIMMU.2015.00009
Bing He, Xiaojie Qiu, Peng Li, Lishan Wang, Qi Lv, Tieliu Shi, HCCNet: an integrated network database of hepatocellular carcinoma Cell Research. ,vol. 20, pp. 732- 734 ,(2010) , 10.1038/CR.2010.67
Jihan Huang, Qianmin Su, juan yang, yinghua lv, yingchun he, junchao chen, ling xu, kun wang, qingshan zheng, Sample sizes in dosage investigational clinical trials: a systematic evaluation. Drug Design Development and Therapy. ,vol. 9, pp. 305- 312 ,(2015) , 10.2147/DDDT.S76135
Jiaping Jin, Guixia Ding, Huaying Bao, Ying Chen, Yuan Han, Fei Zhao, Songming Huang, Aihua Zhang, Correlation between PPAR Gene Polymorphisms and Primary Nephrotic Syndrome in Children. Ppar Research. ,vol. 2013, pp. 927915- 927915 ,(2013) , 10.1155/2013/927915
Philip Dyer, Roger McGilvray, Victoria Robertson, David Turner, Status report from 'double agent HLA': health and disease. Molecular Immunology. ,vol. 55, pp. 2- 7 ,(2013) , 10.1016/J.MOLIMM.2012.08.016