1.12 Bioactivity: Mechanisms

摘要: Bioactive ceramics are known to bond directly bone and stimulate formation. This has led their constantly increasing clinical use. Numerous studies have contributed enhancing our understanding regarding the stimulatory effect of bioactive calcium phosphates on osteoblast function tissue Significant progress been made in revealing solution-mediated surface reactions that take place close ceramics. Advanced analysis methods combined with molecular techniques order facilitate a better transformations bioactive, resorbable glasses serum protein adsorption events associated immersion biological fluids. Increasing knowledge generated differentiation vitro. Furthermore, various maturation vivo studied thereby allowing correlation vitro events. More recent research efforts provided insight into integrin-mediated cell adhesion subsequently activated intracellular signaling pathways regulate including survival. Also ionic dissolution products types involved osteogenesis increasingly years. Current challenges furthermore involve developing appropriate co-culture models, which adequately mimic stem niche can serve as platform, will enable both surface-mediated well effects true situ regenerative be investigated Establishing models include macrophages addition osteoblasts endothelial cells represents very step this direction. Once reaction clearly identified materials created preferentially boost osteogenic cascade thus optimally tailored toward application.