Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping.

作者: Cynthia Sandor , Frédéric Farnir , Sarah Hansoul , Wouter Coppieters , Théo Meuwissen

DOI: 10.1534/GENETICS.106.059329

关键词:

摘要: We herein demonstrate that in the Holstein–Friesian dairy cattle population, microsatellites are as polymorphic on X chromosome autosomes but level of linkage disequilibrium between these markers is higher than autosomes. The latter observation not compatible with small male-to-female ratio prevails this population and results a gonosomal autosomal effective size. It suggests undergoes distinct selective or mutational forces. describe characterize novel Markovian approach to exploit compute probability two chromosomes identical-by-descent conditional flanking marker data. use ensuing probabilities restricted maximum-likelihood search for quantitative trait loci (QTL) affecting 48 traits importance industry provide evidence presence QTL 5 bovine chromosome.

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