Neurite Outgrowth Stimulated by Oxytocin Is Modulated by Inhibition of the Calcium Voltage-Gated Channels
作者： M. Zatkova , A. Reichova , Z. Bacova , V. Strbak , A. Kiss
DOI: 10.1007/S10571-017-0503-3
关键词:
摘要: Neuropeptide oxytocin contributes to the regulation of neuron differentiation and cell morphology. However, precise mechanisms are not yet fully understood. Oxytocin receptor function its coupling calcium entry obvious objects interest in relation Postsynaptic scaffolding proteins including SHANK interact with other synaptic molecules change dendritic SH-SY5Y neuroblastoma line represents a useful neurobiological vitro model study short-term effects on neurite outgrowth underlying mechanisms. In present study, we show that induces an increase intracellular cells. Specificity influx was verified by blockade receptors antagonist L-371,257. Neurite stimulated inhibited specific voltage-gated channel blockers. The exposure cells resulted significant gene expression SHANK1 SHANK3 proteins. Overall, data indicate may contribute known be associated clusters channels at membrane. It appears is, least, part dependent channels.
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