Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
作者： Hong Chen , Lili Zhong , Yuhua Long , Jia Li , Jueheng Wu
DOI: 10.3390/MD10040932
关键词:
摘要: A series of new derivatives (5–29) marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities all compounds evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. 7, 8, 22, 23, 25, 28 29 total showed comparable activity to epirubicin, positive control, tested cancer cell lines. However, these also exhibited cytotoxicity towards cells. structure-activity relationship (SAR) was discussed based on obtained experimental data.
mdpi.com
sci-hub.se 参考文章(30)
Gui'e Xie, Xun Zhu, Qing Li, Minghui Gu, Zhenjian He, Jueheng Wu, Jun Li, Yongcheng Lin, Mengfeng Li, Zhigang She, Jie Yuan, SZ‐685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway British Journal of Pharmacology. ,vol. 159, pp. 689- 697 ,(2010) , 10.1111/J.1476-5381.2009.00577.X
R Charudattan, K V Rao, Bostrycin and 4-deoxybostrycin: two nonspecific phytotoxins produced by Alternaria eichhorniae. Applied and Environmental Microbiology. ,vol. 43, pp. 846- 849 ,(1982) , 10.1128/AEM.43.4.846-849.1982
Chunling Xu, Jiafeng Wang, Ye Gao, Huangyu Lin, Lin Du, Shanshan Yang, Simei Long, Zhigang She, Xiaoling Cai, Shining Zhou, Yongjun Lu, The anthracenedione compound bostrycin induces mitochondria‐mediated apoptosis in the yeast Saccharomyces cerevisiae Fems Yeast Research. ,vol. 10, pp. 297- 308 ,(2010) , 10.1111/J.1567-1364.2010.00615.X
Melvyn Gill, Albin F. Smrdel, Deoxyaustrocortilutein and deoxyaustrocortirubin, tetrahydroanthraquinones from the Genus Cortinarius Phytochemistry. ,vol. 26, pp. 2999- 3001 ,(1987) , 10.1016/S0031-9422(00)84579-3
Khisal A. Alvi, John Rabenstein, Auxarthrol A and auxarthrol B: two new tetrahydoanthraquinones from Auxarthron umbrinum. Journal of Industrial Microbiology & Biotechnology. ,vol. 31, pp. 11- 15 ,(2004) , 10.1007/S10295-003-0106-5
E. STURDIK, L. DROBNICA, Interaction of Cytotoxic Antibiotic Dactylarin with Glycolytic Thiol Enzymes in Ehrlich Ascites Carcinoma Cells The Journal of Antibiotics. ,vol. 34, pp. 708- 712 ,(1981) , 10.7164/ANTIBIOTICS.34.708
Akio Takenaka, Akio Furusaki, Tokunosuké Watanabé, Toshiharu Noda, Teruo Take, Tetsuo Watanabe, Jin-nosuke Abe, The crystal and molecular structure of bostrycin p-bromobenzoate, a derivative of bostrycin Tetrahedron Letters. ,vol. 9, pp. 6091- 6094 ,(1968) , 10.1016/S0040-4039(00)70802-1
T. Noda, T. Take, M. Otani, K. Miyauchi, T. Watanabe, J. Abe, Structure of bostrycin Tetrahedron Letters. ,vol. 9, pp. 6087- 6090 ,(1968) , 10.1016/S0040-4039(00)70801-X
T. Ross Kelly, Jayanta K. Saha, Robert R. Whittle, Bostrycin: structure correction and synthesis Journal of Organic Chemistry. ,vol. 50, pp. 3679- 3685 ,(1985) , 10.1021/JO00220A001
Melvyn Gill, Richard J. Strauch, New tetrahydroanthraquinones from the genus Cortinarius Tetrahedron Letters. ,vol. 26, pp. 2593- 2596 ,(1985) , 10.1016/S0040-4039(00)98845-2