Advanced pancreatic carcinoma: current treatment and future challenges.

摘要: Pancreatic adenocarcinoma is the most lethal of solid tumors and fourth leading cause cancer-related death in North America. Most patients present with locally advanced or metastatic disease that precludes curative resection. These have an extremely poor prognosis. In absence effective screening methods, considerable efforts been made during past decade to identify better systemic treatments. Unfortunately trials not shown a survival advantage for therapies. tandem this increased clinical research, there has also expansion preclinical laboratory investigation. studies revealed many molecular mechanisms involved pancreatic cancer development, which provided insights into why current therapies are ineffective. new discoveries provide some optimism agents inhibiting specific targets will improve outcome overcome resistance standard We review standards care carcinoma outline future directions development treatment strategies.