ToF-SIMS imaging with cluster ion beams

摘要: Molecule-specific imaging using focused ion beams is one of the most powerful applications ToF-SIMS and offers unique surface characterization information. However, many experiments lack necessary sensitivity to properly take advantage sub-100 nm probe size typical liquid metal sources. The yield biomolecules Ga + ions, for example, very small when compared that obtained Cs or SF 5 cluster Most recently, a C 60 source with approaching 1 x 10 -6 m has become available promise expand dramatically. Here, we report on 50×10 polystyrene resin particles used in solid phase synthesis combinatorial libraries assay membrane chemistry single biological cells. Both these examples allow much higher quality images be acquired with, some cases, almost no sample damage. This latter effect opens possibility three-dimensional molecule-specific imaging.