Investigating the integrative role of substrate stiffness, strain, and tone on the functional and phenotypic response of airway smooth muscle in asthmatic airways
作者： Rachel Wise
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摘要: x List of Abbreviations Used xi Chapter 1: Introduction 1 1.1 Thesis Overview 1.2 Asthma Pathology and Remodelling 1.3 Cellular Mechanics 3 1.4 Airway Smooth Muscle Function Phenotype 6 1.4.1 Characteristics Mature ASM Cells 1.4.2 Cell Plasticity 9 1.5 Substrate Stiffness 12 1.6 Strain 15 1.6.1 Deep Inspiration 1.6.2 Fluidization vs. Reinforcement 1.7 Tone 18 1.8 Integrative Response 20 1.9 General Hypothesis 23 1.10 Aims 25 1.10.1 Aim
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