Proximal tubular function in adult rats treated neonatally with enalapril

摘要: Neonatal treatment with angiotensin-converting enzyme (ACE) inhibitors or the angiotensin II type-1 receptor antagonist losartan in rats induces irreversible renal histological abnormalities, mainly papillary atrophy, association an impairment urinary concentrating ability. The aim of present study was to assess proximal tubular function adult treated neonatally enalapril. Male Wistar received daily, intraperitoneal injections either enalapril (10 mg kg -1 ) isotonic saline vehicle from 3 24 days age. In 15-week-old, hydropenic we analysed: (i) iso-osmotic fluid reabsorption using method lithium clearance; and (ii) maximal D-glucose (Tm G ), under pentobarbital anaesthesia. main findings were that enalapril-treated showed: reductions absolute (APRH 2 O) fractional (FPRH tubules O: 0.50 ± 0.02 vs. 0.64 0.03 mL min g KW , P < 0.05; FPRH 58 68 2%, 0.05); a normal Tm . addition, during baseline clearance measurements showed increases urine volume excretion rates sodium potassium, reduction osmolality, whereas glomerular filtration rate effective plasma flow unaltered. These results suggest neonatal ACE inhibition produces irreversible, but differentiated, abnormality function. Thus, development rat seems be dependent on intact renin-angiotensin system, (RAS) neonatally.