Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.

摘要: Superoxide dismutase (SOD) rapidly scavenges superoxide (O2-) and also prolongs the vasorelaxant effects of nitric oxide (NO), thought to be endothelium-derived relaxing factor. This prolongation has been ascribed prevention reaction between O2- with NO. We report that SOD supports a reversible reduction NO NO-. When cyanamide catalase were used generate NO- in presence SOD, was measured by conversion HbO2 MetHb. SOD[Cu(I)] exposed anaerobically, trapped MetHb forming nitrosylmyoglobin. generated 3-morpholinosydnonimine hydrochloride or similar reductant formed, which reduced compound II promoted formation [Fe(III)]-NO complex. It is, therefore, conceivable may protect factor mechanism addition scavenging physiologically important form