Changes in motor nerve terminals during bupivacaine-induced postsynaptic deprivation.

摘要: The local anaesthetic agent bupivacaine induces a rapid degeneration of muscle cells when injected in the sternocleidomastoid adult rat with no damage to intramuscular nerves. Nevertheless, silver impregnation and electron microscopy reveal sequence retraction sprouting motor nerve endings during period bupivacaine-induced cell deprivation by necrosis. These morphological changes seem be qualitatively similar growth phenomena described as forming part remodelling process affecting normal untreated neuromuscular junctions amphibia mammals. results are discussed context regulatory mechanisms governing maintenance terminals.