Characterization of Axonal Disease in Patients with Multiple Sclerosis Using High-Gradient-Diffusion MR Imaging
作者： Susie Y. Huang , Sean M. Tobyne , Aapo Nummenmaa , Thomas Witzel , Lawrence L. Wald
DOI: 10.1148/RADIOL.2016151582
关键词:
摘要: Purpose To evaluate the ability of high-gradient-diffusion magnetic resonance (MR) imaging by using gradient strengths up to 300 mT/m depict axonal disease in lesions and normal-appearing white matter (NAWM) patients with multiple sclerosis (MS) compare MR findings these those healthy control subjects. Materials Methods In this HIPAA-compliant institutional review board-approved prospective study which all subjects provided written informed consent, six relapsing-remitting MS underwent diffusion-weighted a range diffusion weightings performed 3-T human imager mT/m. A model intra-axonal, extra-axonal, free water was fitted obtain estimates axon diameter density. Differences density between NAWM were assessed nonparametric Wilcoxon matched-pairs signed rank test, differences Mann-Whitney U test. Results showed increased mean (10.3 vs 7.9 μm genu, 10.4 9.3 body, 10.6 8.2 splenium; P < .05) decreased ([0.48 1.1] × 10(10)/m(2) [0.40 0.70] [0.35 compared adjacent NAWM. No significant difference or detected Conclusion High-gradient-diffusion can be used characterize MS, results that agree known trends from neuropathologic data showing when (©) RSNA, 2016 Online supplemental material is available for article.
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sci-hub.se 参考文章(25)
Tim B. Dyrby, Lise V. S⊘gaard, Matt G. Hall, Maurice Ptito, Daniel. C. Alexander, Contrast and stability of the axon diameter index from microstructure imaging with diffusion MRI Magnetic Resonance in Medicine. ,vol. 70, pp. 711- 721 ,(2013) , 10.1002/MRM.24501
Daniel C. Alexander, Penny L. Hubbard, Matt G. Hall, Elizabeth A. Moore, Maurice Ptito, Geoff J.M. Parker, Tim B. Dyrby, Orientationally invariant indices of axon diameter and density from diffusion MRI NeuroImage. ,vol. 52, pp. 1374- 1389 ,(2010) , 10.1016/J.NEUROIMAGE.2010.05.043
K. Setsompop, R. Kimmlingen, E. Eberlein, T. Witzel, J. Cohen-Adad, J.A. McNab, B. Keil, M.D. Tisdall, P. Hoecht, P. Dietz, S.F. Cauley, V. Tountcheva, V. Matschl, V.H. Lenz, K. Heberlein, A. Potthast, H. Thein, J. Van Horn, A. Toga, F. Schmitt, D. Lehne, B.R. Rosen, V. Wedeen, L.L. Wald, Pushing the limits of in vivo diffusion MRI for the Human Connectome Project NeuroImage. ,vol. 80, pp. 220- 233 ,(2013) , 10.1016/J.NEUROIMAGE.2013.05.078
Ranjan Dutta, Bruce D. Trapp, Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Progress in Neurobiology. ,vol. 93, pp. 1- 12 ,(2011) , 10.1016/J.PNEUROBIO.2010.09.005
Jorge Jovicich, Silvester Czanner, Douglas Greve, Elizabeth Haley, Andre van der Kouwe, Randy Gollub, David Kennedy, Franz Schmitt, Gregory Brown, James MacFall, Bruce Fischl, Anders Dale, Reliability in multi-site structural MRI studies: Effects of gradient non-linearity correction on phantom and human data NeuroImage. ,vol. 30, pp. 436- 443 ,(2006) , 10.1016/J.NEUROIMAGE.2005.09.046
Klaus Schmierer, Claudia A.M. Wheeler-Kingshott, Phil A. Boulby, Francesco Scaravilli, Daniel R. Altmann, Gareth J. Barker, Paul S. Tofts, David H. Miller, Diffusion tensor imaging of post mortem multiple sclerosis brain NeuroImage. ,vol. 35, pp. 467- 477 ,(2007) , 10.1016/J.NEUROIMAGE.2006.12.010
E. Auerbach, D. Barch, T.E.J. Behrens, R. Bucholz, A. Chang, L. Chen, M. Corbetta, S.W. Curtiss, S. Della Penna, D. Feinberg, M.F. Glasser, N. Harel, A.C. Heath, L. Larson-Prior, D. Marcus, G. Michalareas, S. Moeller, R. Oostenveld, S.E. Petersen, F. Prior, B.L. Schlaggar, S.M. Smith, A.Z. Snyder, J. Xu, E. Yacoub, D.C. Van Essen, K. Ugurbil, The Human Connectome Project: A data acquisition perspective NeuroImage. ,vol. 62, pp. 2222- 2231 ,(2012) , 10.1016/J.NEUROIMAGE.2012.02.018
Susie Y. Huang, Aapo Nummenmaa, Thomas Witzel, Tanguy Duval, Julien Cohen-Adad, Lawrence L. Wald, Jennifer A. McNab, The impact of gradient strength on in vivo diffusion MRI estimates of axon diameter NeuroImage. ,vol. 106, pp. 464- 472 ,(2015) , 10.1016/J.NEUROIMAGE.2014.12.008
Chia-Wen Chiang, Yong Wang, Peng Sun, Tsen-Hsuan Lin, Kathryn Trinkaus, Anne H. Cross, Sheng-Kwei Song, Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema. NeuroImage. ,vol. 101, pp. 310- 319 ,(2014) , 10.1016/J.NEUROIMAGE.2014.06.064
E. Bergers, J.C.J. Bot, C.J.A. De Groot, C.H. Polman, G.J. Lycklama a Nijeholt, J.A. Castelijns, P. van der Valk, F. Barkhof, Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions Neurology. ,vol. 59, pp. 1766- 1771 ,(2002) , 10.1212/01.WNL.0000036566.00866.26