Aortic correlates of clinical markers of large artery structure and function. Effects of aging and hypertension.

摘要: Background and aims: Non-invasive measures of large artery structure function — such as aorto-femoral pulse wave velocity (PWV), arterial compliance (AC) common carotid intima-media thickness (CCA IMT) can predict new CV events, independently traditional risk factors. However, neither their relations with aorta properties nor the effects aging hypertension on those are yet clear. Methods Results: 40 subjects (18 M, 22 F; mean age 60±16 yrs, range 21–83 yrs) free any acute event, valve disease or atrial fibrillation, were studied. Aortic IMT, diastolic diameter (D) distensibility (Dist) measured by transesophageal echocardiography at three different levels: ascending (AA), distal aortic arch (Aarc) descending (DA). PWV was Complior®. AC ratio stroke volume to pressure. CCA IMT ultrasonography in diastole. The Dist, D each segment introduced alternatively into regression models. After controlling for age, sex, factors prevalent disease, showed a significant positive association proximal segments, but no aorta; wall negative distensibility; positively associated thickness, not explored property aorta. None these relationships differed between younger older, normotensive hypertensive subjects. Conclusions: equivalent respect properties, so that seems reflect function, structure. Future studies needed confirm whether identify pathogenetic mechanism, which may be target therapeutic strategies.