Subcutaneously applied magnesium protects reliably against quinolinate-induced (NMDA)-mediated neurodegeneration and convulsions in rats: Are there therapeutical implications?

摘要: Abstract Quinolinate (QUIN), an agonist of the N- methyl- d -aspartate (NMDA) subtype glutamate receptor, was used to model glutamate-induced primary or secondary brain damage. Rats intracerebroventricularly injected with QUIN (1 μmol in 2 μl) showed convulsive reactions and heavy neurodegeneration hippocampal formation. MgSO 4 M solution subcutaneously; 0.6 0.3 g/kg) found protect completely against neurotoxicity if administered simultaneously 1 h after exposure QUIN. Preliminarily, LD 50 for estimated approximately at 1.2 g/kg. The application magnesium is discussed be a potentially powerful therapeutic principle case injury disorders.