Streptococcus pneumoniae Transposon Tn1545/Tn6003 Changes to Tn6002 Due to Spontaneous Excision in Circular Form of the erm(B)- and aphA3-Containing Macrolide-Aminoglycoside-Streptothricin (MAS) Element
作者： Claudio Palmieri , Marina Mingoia , Orietta Massidda , Eleonora Giovanetti , Pietro E. Varaldo
DOI: 10.1128/AAC.01487-12
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摘要: The macrolide-aminoglycoside-streptothricin (MAS) element, an ∼4.2-kb insertion containing erm(B) and aphA3 resistance determinants, distinguishes Streptococcus pneumoniae transposon Tn1545/Tn6003 from Tn6002. Here, it is shown to be unstable genetic element that, although lacks recombinase genes, can exploit long, erm(B)-containing direct repeats acting as att sites for spontaneous excision that may result in loss. Consequent excision, which RecA independent, changes In pneumococcal populations harboring Tn1545/Tn6003, the latter appears coexist with
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