Deletion of gene for multidrug resistance in acute myeloid leukaemia with inversion in chromosome 16: prognostic implications
作者： B.J Kuss , H.J Eyre , S.A Lane , J.K Nancarrow , S.A Whitmore
DOI: 10.1016/S0140-6736(94)92938-6
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摘要: Abstract Acute myeloid leukaemia (AML) associated with an inversion in chromosome 16 has a relatively favourable prognosis. The AML subclass most commonly this chromosomal abnormality is acute myelomonocytic abnormal eosinophils. In some patients the lesion results deletion of MRP, gene for multidrug resistance protein. This proximal to primary breakpoint and loss its function may play key role determining outcome AML. We have demonstrated MRP by situ hybridisation, dosage studies studying heterogeneity flanking microsatellite marker. Among 13 was detected 5 while 7 had no deletion. Deletion longer time from diagnosis until death or relapse complete remission (p=0·007). These findings provide important insight into biology suggest that deletion, as molecular analysis,
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