Cardiac Per2 Functions as Novel Link between Fatty Acid Metabolism and Myocardial Inflammation during Ischemia and Reperfusion Injury of the Heart

作者: Stephanie Bonney , Doug Kominsky , Kelley Brodsky , Holger Eltzschig , Lori Walker

DOI: 10.1371/JOURNAL.PONE.0071493

关键词:

摘要: … ischemia, we measured lactate during reperfusion in Per1 −/− , Per2 −/− or wildtype mice. As lactate … role of Per2 in controlling lactate production during myocardial ischemia, we next …

参考文章(64)
Binhai Zheng, David W. Larkin, Urs Albrecht, Zhong Sheng Sun, Marijke Sage, Gregor Eichele, Cheng Chi Lee, Allan Bradley, The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature. ,vol. 400, pp. 169- 173 ,(1999) , 10.1038/22118
Timothy S. Zheng, Richard A. Flavell, Apoptosis. All's well that ends dead. Nature. ,vol. 400, pp. 410- 411 ,(1999) , 10.1038/22659
Jonathan P Wisor, Bruce F O'Hara, Akira Terao, Chris P Selby, Thomas S Kilduff, Aziz Sancar, Dale M Edgar, Paul Franken, A role for cryptochromes in sleep regulation. BMC Neuroscience. ,vol. 3, pp. 20- 20 ,(2002) , 10.1186/1471-2202-3-20
Ju-Yun Tsai, Petra C. Kienesberger, Thomas Pulinilkunnil, Mary H. Sailors, David J. Durgan, Carolina Villegas-Montoya, Anil Jahoor, Raquel Gonzalez, Merissa E. Garvey, Brandon Boland, Zachary Blasier, Tracy A. McElfresh, Vijayalakshmi Nannegari, Chi-Wing Chow, William C. Heird, Margaret P. Chandler, Jason R. B. Dyck, Molly S. Bray, Martin E. Young, Direct Regulation of Myocardial Triglyceride Metabolism by the Cardiomyocyte Circadian Clock Journal of Biological Chemistry. ,vol. 285, pp. 2918- 2929 ,(2010) , 10.1074/JBC.M109.077800
Steven M. Haffner, The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease. American Journal of Cardiology. ,vol. 97, pp. 3- 11 ,(2006) , 10.1016/J.AMJCARD.2005.11.010
Geoffrey H. Tofler, Damian Brezinski, Andrew I. Schafer, Charles A. Czeisler, John D. Rutherford, Stefan N. Willich, Ray E. Gleason, Gordon H. Williams, James E. Muller, Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death New England Journal of Medicine. ,vol. 316, pp. 1514- 1518 ,(1987) , 10.1056/NEJM198706113162405
Finn Tüchsen, Harald Hannerz, Hermann Burr, A 12 year prospective study of circulatory disease among Danish shift workers Occupational and Environmental Medicine. ,vol. 63, pp. 451- 455 ,(2006) , 10.1136/OEM.2006.026716
Tobias Eckle, Holger K. Eltzschig, Toll-like Receptor Signaling during Myocardial Ischemia Anesthesiology. ,vol. 114, pp. 490- 492 ,(2011) , 10.1097/ALN.0B013E31820A4D78
Tobias Eckle, Katherine Hartmann, Stephanie Bonney, Susan Reithel, Michel Mittelbronn, Lori A Walker, Brian D Lowes, Jun Han, Christoph H Borchers, Peter M Buttrick, Douglas J Kominsky, Sean P Colgan, Holger K Eltzschig, Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia Nature Medicine. ,vol. 18, pp. 774- 782 ,(2012) , 10.1038/NM.2728