Cellular and molecular signals in T cell differentiation.

摘要: The thymic epithelium exerts its differentiative effects through several mechanisms, involving direct contact with stem cells as well secretion of various hormones. Indirect and evidence suggests that the thymus produces chemotactic factors for colonize anlage. also maturational which act upon have undergone primary differentiation by epithelium. chemical characteristics these hormones their mode action at cellular level (high affinity receptors, metabolic effects, target cells) are partly known. Their relationship T cell such Interleukin-2--produced in periphery endowed strong capacity--is intriguing, more so because not only within but affect peripheral after they emigrated from thymus.