Neurotransmitter receptors as targets for pesticides
作者： Mohyee E. Eldefrawi , Amira T. Eldefrawi
DOI: 10.1080/03601238309372358
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摘要: Nicotinic and muscarinic acetylcholine (ACh) receptors have been identified biochemically by means of their specific binding [3H] alpha-bungarotoxin ([3H]alpha-BGT) [3H]quinuclidinyl benzilate, respectively. There are some differences in the drug specificities, sensitivities to active group reagents, these insects when compared those vertebrates. Also, insect brain contains more nicotinic than receptors, while reverse is found mammalian brain. Insect a third kind putative ACh-receptor that relatively soluble both its pharmacology but does not bind alpha-BGT. Toxic nicotine analogs it with high affinities. Several organophosphorus carbamate insecticides nereistoxin affinities electric organ Torpedo. A few chlorinated hydrocarbon derivatives interact Torpedo ACh-receptors, at 'receptor' sites allosteric or 'channel' (which [3H]perhydrohistrionicotoxin). also receptors. The most potent on acaricide chlorobenzilate. Pyrethrins synthetic pyrethroids channel ACh-receptor, though receptor sites. Another binds ACh-receptors organic inorganic mercury compounds, which rat Thus, neurotransmitter act as molecular targets, primary secondary for different pesticides.
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