Synthetic inhibitors of bacterial and mammalian interstitial collagenases.

摘要: Publisher Summary This chapter reviews recent progress in the development of both bacterial and mammalian collagenase inhibitors. To facilitate this goal, one provides relevant biochemical background information on these enzymes their assay methods. The also discusses many roles that collagenases are believed to play normal pathological processes. summarizes inhibitors have been developed results use a few physiological assays. extracellular matrix humans is composed variety macromolecules serve structural organizational roles. These include collagens, elastin, proteoglycans, fibronectin, laminin, other poorly characterized minor substituents. collagens account for about one-third human protein primary components most connective tissues including skin, bone, teeth, tendon, cartilage, basement membrane, blood vessels, cornea vitreous humor. They ubiquitous higher organisms, which they occur as aggregates function proteins. term collagen actually refers class molecules derived from or several multigene families.