Impact of Obesity on Plasma Natriuretic Peptide Levels

摘要: Background— The mechanisms linking obesity to hypertension have not been established, but sodium retention and excessive sympathetic tone are key contributors. natriuretic peptides important regulators of homeostasis neurohormonal activation, raising the possibility that obese individuals an impaired peptide response. Methods Results— We examined relations plasma B-type (BNP) N-terminal proatrial (N-ANP) body mass index in 3389 Framingham Study participants (1803 women) without heart failure. Multivariable regression analyses were performed, adjusting for clinical echocardiographic covariates. BNP levels below assay detection limit N-ANP lowest sex-specific quartile categorized as low. Multivariable-adjusted mean lean (<25 kg/m2), overweight (25 29.9 (≥30 kg/m2) men 21.4, 15.5, 12.7 pg/mL, respectively (trend P <0.0001). Corresponding values women 21.1, 16.3, 13.1 pg/mL <0.001). A similar pattern was noted N-ANP. Obese had higher odds having low (multivariable-adjusted ratios: men, 2.51; 95% CI, 1.71 3.68; women, 1.84; 1.32 2.58) (odds 4.81; 2.98 7.76; 2.85; 2.01 4.04) compared with individuals. Diabetes also associated levels, negative effects diabetes on additive. Conclusions— circulating which may contribute their susceptibility hypertension-related disorders. Received August 12, 2003; revision received November 11, accepted 14, 2003.