Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts

摘要: The immunological barrier currently precludes the clinical utilization of allogeneic stem cells. Although glial-restricted progenitors have become attractive candidates to treat a wide variety neurological diseases, their survival in immunocompetent recipients is limited. In this study, we adopted short-term, systemically applicable co-stimulation blockade-based strategy using CTLA4-Ig and anti-CD154 antibodies modulate T-cell activation context progenitor transplantation. We found that blockade successfully prevented rejection from mouse brains. long-term engrafted myelinated dysmyelinated adult brains within one month. Furthermore, identified set plasma miRNAs whose levels specifically correlated dynamic changes immunoreactivity as such could serve biomarkers for graft or tolerance. put forward successful induce alloantigen-specific hyporesponsiveness towards cells CNS, which will foster effective therapeutic application