Methadyl Acetate and Methadone

摘要: Heroin addicts were recruited for a 14-week open clinical comparison of methadone hydrochloride and methadyl acetate. Patients randomly assigned to acetate clinic in which was dispensed patients three times per week or six days week. No statistically significant differences observed between groups retention rates, illicit drug use, employment arrest rates. The group treated with had more dropouts the first seven weeks than second weeks: this pattern reversed methadone-treated group. (P=.01). Spontaneously reported symptoms suggest that induction may be clinically variable phenomenon methadone. reduction number visits not source variance treatment effectiveness. (JAMA237:138-142, 1977)