Resolution of nonalcoholic steatohepatits after gastric bypass surgery

摘要: Background: Nonalcoholic fatty liver disease (NAFLD) has been increasingly recognized as a common chronic condition. Previous studies have variable regarding the histological outcomes after rapid weight loss. The aim of this study was to characterize histopathologic changes in NASH following laparoscopic Roux-en-Y Gastric Bypass surgery (LRYGBP). Methods: We retrospectively analyzed paired needle biopsies taken during and LRYGBP 39 patients according recent NIH-based NAFLD criteria. Results: cohort included 33 females 6 males (range 24-57 years). 23 (58.9%) had steatohepatitis, 12 with (30.7%), 4 were normal (10.2%). Follow-up performed at mean interval 18 months 6-41 months). No significant differences length or number portal tracts between noted. decrease BMI 50.2 kg 18.2 kg/m 2 , respectively. initial prevalence hepatic pathology: steatosis (89.7%), hepatocellular ballooning (58.9%), centrilobular/perisinusoidal fibrosis (50%) improved significantly LRYGBP: (2.9%), (0%), centrilobular (25%). Mitigation lobular inflammation score (2.23±0.63 vs 1.95±0.56, P=0.01) stage (1.14±1.05 0.72±0.97, P=0.002) also However, no improvements detected tract fibrosis. Conclusions: Over period months, resolution occurs LRYGBP. Long-term are warranted assess for potential regions relapse that could result regain malnutrition.