Galactosylated polymeric carriers for liver targeting of sorafenib

摘要: In this paper, we describe the preparation of liver-targeted polymeric micelles potentially able to carry sorafenib hepatocytes for treatment hepatocarcinoma (HCC), exploiting presence carbohydrate receptors, ASGPR. These were prepared starting from a galactosylated polylactide-polyaminoacid conjugate. This latter was obtained by chemical reaction α,β-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-d,l-aspartamide (PHEA-EDA) with polylactic acid (PLA), and subsequent lactose, leading PHEA-EDA-PLA-GAL copolymer. Liver-targeted sorafenib-loaded in aqueous media at low copolymer concentration value nanometer size slightly positive zeta potential. Biodistribution studies on mice demonstrated, after oral administration loaded micelles, preferential accumulation into liver. finding raises hope terms future drug delivery strategy targeted liver HCC treatment.