GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity.
作者： Nobutaka Ohgami , Ichiro Yajima , Masashi Kato , Cunchao Zou , Osamu Yamanoshita
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摘要: It is well known that heterotrimeric G protein composed of a Gα-subunit and Gβγ-dimer promotes cancer characteristics. Our recent study showed reduced γ2 subunit (Gng2/GNG2) expression levels in malignant melanoma cells compared with those benign melanocytic both mice humans. also GNG2 alone augmented proliferation cells. To our knowledge, however, there no evidence showing an effect Gng2/GNG2 on metastasis any cancers including melanoma. In his study, we first prepared GNG2-overexpressed SK-Mel28 human cells, which level was undetectably low. Migration invasion activities the were suppressed up to 1/10th, decreased activity focal adhesion kinase (FAK). We then found A375M, highly metastatic cell line, significantly lower than A375P, parental line A375M. finally knockdown A375P enhanced migration increased FAK activity. Taken together, results suggest overexpression inhibits Thus, might be candidate molecular targets prevention therapy for
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